Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

Abstract excerpt

The beta cell-specific glucose-sensitive factor (GSF), which binds the A3 motif of the rat I and human insulin promoters, is modulated by extracellular glucose. A single mutation in the GSF binding site of the human insulin promoter abolishes the stimulation by high glucose only in normal islets, supporting the suggested physiological role of GSF in the glucose-regulated expression of the insulin gene. GSF...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diet, Metabolism, and Disease
• Share to Metabolism, Diabetes, and Cancer
• Share to Pancreatic function and diabetes