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Article

Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 1996

Moates J M, Shelton K D, Magnuson M A

Abstract excerpt

The upstream glucokinase (GK) promoter is expressed specifically in several different neural/neuroendocrine (NE) cell types, including the pancreatic beta-cell and pituitary corticotrope. Previously, a mutational and evolutionary analysis of this promoter identified two identical 9-bp motifs (TGGTCACCA) termed Pal-1 and Pal-2 that are essential for high level expression in HIT M2.2.2 cells, an insulinoma cell...

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PMID: 8776732
DOI: 10.1210/mend.10.6.8776732

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