Article
Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 1996
Moates J M, Shelton K D, Magnuson M A
Abstract excerpt
The upstream glucokinase (GK) promoter is expressed specifically in several different neural/neuroendocrine (NE) cell types, including the pancreatic beta-cell and pituitary corticotrope. Previously, a mutational and evolutionary analysis of this promoter identified two identical 9-bp motifs (TGG...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Binding Sites
- Cricetinae
- Cross-Linking Reagents
- Glucokinase
- Islets of Langerhans
- Lasers
- Mice
- Mutation
- Pituitary Neoplasms
- Promoter Regions, Genetic
- Proteins
- Transcriptional Activation
- Tumor Cells, Cultured
- Ultraviolet Rays