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Article

Identification of a novel PDX-1 binding site in the human insulin gene enhancer.

The Journal of biological chemistry - 21 May 2004

Le Lay John, Matsuoka Taka-Aki, Henderson Eva, Stein Roland

Abstract excerpt

Islet beta cell type-specific transcription of the insulin gene is regulated by a number of cis-acting elements found within the proximal 5'-flanking region. The control sequences conserved between mammalian insulin genes are acted upon by transcription factors, like PDX-1 and BETA-2, that are also involved in islet beta cell function and formation. In the current study, we investigated the contribution to human...

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Source

Identifiers

PMID: 15028719
DOI: 10.1074/jbc.M312673200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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