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Article

Positive and negative regulation of the human insulin gene by multiple trans-acting factors.

The Journal of biological chemistry - 15 May 1990

Boam D S, Clark A R, Docherty K

Abstract excerpt

Tissue-specific expression of the human insulin gene is regulated by cis-acting DNA elements 5' to the transcription start site. Deletion of the 5' region of the human insulin gene between nucleotides -279 and -258 caused a 25-fold rise in transcriptional activity whereas further deletion to nucleotide -229 reduced transcription activity 25-fold. In vitro analysis of protein binding in the 5' regulatory region...

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PMID: 2186040

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