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Article

Pta1, a component of yeast CF II, is required for both cleavage and poly(A) addition of mRNA precursor.

Molecular and cellular biology - 1 Nov 1999

Zhao J, Kessler M, Helmling S, O'Connor J P, Moore C

Abstract excerpt

CF II, a factor required for cleavage of the 3' ends of mRNA precursor in Saccharomyces cerevisiae, has been shown to contain four polypeptides. The three largest subunits, Cft1/Yhh1, Cft2/Ydh1, and Brr5/Ysh1, are homologs of the three largest subunits of mammalian cleavage-polyadenylation specificity factor (CPSF), an activity needed for both cleavage and poly(A) addition. In this report, we show by protein...

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Share to Basic-Leucine Zipper Transcription Factors
Share to mRNA Cleavage and Polyadenylation Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to RNA Precursors

Share to RNA Processing, Post-Transcriptional

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Source

Open in PubMed Open full text

Identifiers

PMID: 10523662
DOI: 10.1128/MCB.19.11.7733
PMCID: PMC84822

Genes

CYC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pta1, a component of yeast CF II, is required for both cleavage and poly(A) addition of mRNA precursor.PMID 10523662Read ↗

A multisubunit 3' end processing factor from yeast containing poly(A) polymerase and homologues of the subunits of mammalian cleavage and polyadenylation specificity factor.Semantic proximity Read ↗

The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation.Semantic proximity Read ↗

Distinct roles of two Yth1p domains in 3'-end cleavage and polyadenylation of yeast pre-mRNAs.Semantic proximity Read ↗

PCF11 encodes a third protein component of yeast cleavage and polyadenylation factor I.Semantic proximity Read ↗

Genetic analysis of polyadenylation patterns reveals distinct classes of yeast genes and local chromatin effects on Pol II elongation.Semantic proximity Read ↗

Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor.Semantic proximity Read ↗

Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF).Semantic proximity Read ↗

RNA14 and RNA15 proteins as components of a yeast pre-mRNA 3'-end processing factor.Semantic proximity Read ↗

The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation.Semantic proximity Read ↗

Involvement of Pta1, Pcf11 and a KlCYC1 AU-rich element in alternative RNA 3'-end processing selection in yeast.Semantic proximity Read ↗

Evidence for a complex of transcription factor IIB with poly(A) polymerase and cleavage factor 1 subunits required for gene looping.Semantic proximity Read ↗

Fip1 regulates the activity of Poly(A) polymerase through multiple interactions.Semantic proximity Read ↗

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