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Article

The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation.

Nucleic acids research - 15 Jul 2003

Kyburz Andrea, Sadowski Martin, Dichtl Bernhard, Keller Walter

Abstract excerpt

Cleavage and polyadenylation factor (CPF) is a multi-protein complex that functions in pre-mRNA 3'-end formation and in the RNA polymerase II (RNAP II) transcription cycle. Ydh1p/Cft2p is an essential component of CPF but its precise role in 3'-end processing remained unclear. We found that mutations in YDH1 inhibited both the cleavage and the polyadenylation steps of the 3'-end formation reaction in vitro....

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Identifiers

PMID: 12853609
DOI: 10.1093/nar/gkg478
PMCID: PMC167639

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The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation.PMID 12853609Read ↗

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The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site.Semantic proximity Read ↗

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