Article
The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation.
PloS one - 1 Jan 2011
Holbein Sandra, Scola Simonetta, Loll Bernhard, Dichtl Beatriz Solange, Hübner Wolfgang, Meinhart Anton, Dichtl Bernhard
Abstract excerpt
Cleavage factor IA (CF IA), cleavage and polyadenylation factor (CPF), constitute major protein complexes required for pre-mRNA 3' end formation in yeast. The Clp1 protein associates with Pcf11, Rna15 and Rna14 in CF IA but its functional role remained unclear. Clp1 carries an evolutionarily conserved P-loop motif that was previously shown to bind ATP. Interestingly, human and archaean Clp1 homologues, but not...
Topics
- Adenosine Triphosphate
- Mutation
- Protein Binding
- RNA, Fungal
- RNA, Messenger
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription, Genetic
- mRNA Cleavage and Polyadenylation Factors