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Article

Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor.

Nucleic acids research - 15 Mar 2003

Tacahashi Yoko, Helmling Steffen, Moore Claire L

Abstract excerpt

Yth1, a subunit of yeast Cleavage Polyadenylation Factor (CPF), contains five CCCH zinc fingers. Yth1 was previously shown to interact with pre-mRNA and with two CPF subunits, Brr5/Ysh1 and the polyadenylation-specific Fip1, and to act in both steps of mRNA 3' end processing. In the present study, we have identified new domains involved in each interaction and have analyzed the consequences of mutating these...

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Identifiers

PMID: 12626716
DOI: 10.1093/nar/gkg265
PMCID: PMC152867

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