Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long‐Term Treatment with Antidepressants Increases Glucocorticoid Receptor Binding and Gene Expression in Cultured Rat Hippocampal Neurones

1 Nov 1999

Abstract excerpt

Since the glucocorticoid receptor (GR) and/or mineralocorticoid receptor (MR) in the hippocampus have been implicated in cortisol feedback of the hypothalamus-pituitary-adrenal (HPA) axis, abnormalities in those receptors might underlie the hyperactivity of the HPA axis described in patients with major depression. Animal studies have shown that long-term in-vivo treatment with antidepressants up-regulates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hormonal Regulation and Hypertension
Share to Neuroendocrine regulation and behavior
Share to Stress Responses and Cortisol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10520140
DOI: 10.1046/j.1365-2826.1999.00405.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long‐Term Treatment with Antidepressants Increases Glucocorticoid Receptor Binding and Gene Expression in Cultured Rat Hippocampal NeuronesPMID 10520140Read ↗

Modulation of Glucocorticoid Receptor Gene Expression by Antidepressant DrugsSemantic proximity Read ↗

Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cellsSemantic proximity Read ↗

A translational approach to clinical practice via stress-responsive glucocorticoid receptor signalingSemantic proximity Read ↗

Glucocorticoid Receptor Function<i>In Vitro</i>in Patients with Major DepressionSemantic proximity Read ↗

Heterodimerization of Mineralocorticoid and Glucocorticoid Receptors at a Novel Negative Response Element of the 5-HT1A Receptor GeneSemantic proximity Read ↗

Increased Cortisol and Antiglucocorticoid Therapy in Mood Disorders: The Hippocampus as a Potential Drug TargetSemantic proximity Read ↗

Neurochemical and behavioral alterations in glucocorticoid receptor-impaired transgenic mice after chronic mild stress.Semantic proximity Read ↗

Administration of the glutamate-modulating drug riluzole after stress reverses its delayed effects on the amygdalaSemantic proximity Read ↗

Transcriptional effects of glucocorticoid receptors in the dentate gyrus increase anxiety-related behaviors.Semantic proximity Read ↗

Depressive-like phenotype induced by prenatal dexamethasone in mice is reversed by desipramine.Semantic proximity Read ↗

Functional implications of brain corticosteroid receptor diversity.Semantic proximity Read ↗

A variant of the neuronal amino acid transporter SLC6A15 is associated with ACTH and cortisol responses and cognitive performance in unipolar depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.