Article
Functional implications of brain corticosteroid receptor diversity.
Cellular and molecular neurobiology - 1 Aug 1993
de Kloet E R, Oitzl M S, Joëls M
Abstract excerpt
1. Corticosteroids readily enter the brain and control gene expression in nerve cells via binding to intracellular receptors, which act as gene transcription factors. In the rat brain corticosterone binds to mineralocorticoid receptors (MRs) with a 10-fold higher affinity than to glucocorticoid receptors (GRs). As a consequence, these MRs are extensively occupied under basal resting conditions, while substantial...
Topics
- Animals
- Brain
- Genetic Variation
- Hippocampus
- Homeostasis
- Humans
- Learning
- Memory
- Models, Neurological
- RNA, Messenger
- Receptors, Glucocorticoid
- Receptors, Mineralocorticoid