Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucocorticoid Receptor Function<i>In Vitro</i>in Patients with Major Depression

1 Dec 2004

Abstract excerpt

Clinical studies have demonstrated an impairment of glucocorticoid receptor (GR)-mediated negative feedback on the hypothalamic--pituitary--adrenal (HPA) axis in patients with major depression (GR resistance), and its resolution by antidepressant treatment. Interestingly, a number of studies have also demonstrated that GR function is reduced in vitro, in peripheral tissues of depressed patients, as shown by a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hormonal Regulation and Hypertension
Share to Stress Responses and Cortisol
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16019586
DOI: 10.1080/10253890500069650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucocorticoid Receptor Function<i>In Vitro</i>in Patients with Major DepressionPMID 16019586Read ↗

Polymorphisms of the glucocorticoid receptor gene and major depression.Semantic proximity Read ↗

Glucocorticoid-independent modulation of GR activity: Implications for immunotherapySemantic proximity Read ↗

A translational approach to clinical practice via stress-responsive glucocorticoid receptor signalingSemantic proximity Read ↗

Glucocorticoid Receptor Polymorphisms in Major DepressionSemantic proximity Read ↗

Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cellsSemantic proximity Read ↗

Deciphering the Dichotomy: The Role of Glucocorticoid Receptor Isoforms in Cortisol’s Paradoxical Impact on Reproduction and PregnancySemantic proximity Read ↗

Acquired Glucocorticoid Resistance Due to Homologous Glucocorticoid Receptor Downregulation: A Modern Look at an Age-Old ProblemSemantic proximity Read ↗

Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disordersSemantic proximity Read ↗

Depression pathogenesis and treatment: what can we learn from blood mRNA expression?Semantic proximity Read ↗

The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness.Semantic proximity Read ↗

Antidepressants, but not antipsychotics, modulate GR function in human whole blood: An insight into molecular mechanismsSemantic proximity Read ↗

Modulation of Glucocorticoid Receptor Gene Expression by Antidepressant DrugsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.