Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterodimerization of Mineralocorticoid and Glucocorticoid Receptors at a Novel Negative Response Element of the 5-HT1A Receptor Gene

1 Apr 2001

Abstract excerpt

Negative regulation of neuronal serotonin (5-HT1A) receptor levels by glucocorticoids in vivo may contribute to depression. Both types I (mineralocorticoid) and II (glucocorticoid) receptors (MR and GR, respectively) participate in corticosteroid-induced transcriptional repression of the 5-HT1A gene; however, the precise mechanism is unclear. A direct repeat 6-base pair glucocorticoid response element (GRE)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen and related hormone effects
Share to Hormonal Regulation and Hypertension
Share to Stress Responses and Cortisol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11278286
DOI: 10.1074/jbc.m005363200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterodimerization of Mineralocorticoid and Glucocorticoid Receptors at a Novel Negative Response Element of the 5-HT1A Receptor GenePMID 11278286Read ↗

Ligand-Induced Repression of the Glucocorticoid Receptor Gene Is Mediated by an NCoR1 Repression Complex Formed by Long-Range Chromatin Interactions with Intragenic Glucocorticoid Response ElementsSemantic proximity Read ↗

Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cellsSemantic proximity Read ↗

Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptorsSemantic proximity Read ↗

The structural basis of direct glucocorticoid-mediated transrepression.Semantic proximity Read ↗

Modulation of Glucocorticoid Receptor Gene Expression by Antidepressant DrugsSemantic proximity Read ↗

A translational approach to clinical practice via stress-responsive glucocorticoid receptor signalingSemantic proximity Read ↗

The ligand-dependent interaction of mineralocorticoid receptor with coactivator and corepressor peptides suggests multiple activation mechanisms.Semantic proximity Read ↗

Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genesSemantic proximity Read ↗

Long‐Term Treatment with Antidepressants Increases Glucocorticoid Receptor Binding and Gene Expression in Cultured Rat Hippocampal NeuronesSemantic proximity Read ↗

Functional implications of brain corticosteroid receptor diversity.Semantic proximity Read ↗

Identification of a mineralocorticoid/glucocorticoid response element in the human Na/K ATPase alpha1 gene promoter.Semantic proximity Read ↗

Identification of a glucocorticoid response element in the rat beta2-adrenergic receptor gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.