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Article

Transcriptional effects of glucocorticoid receptors in the dentate gyrus increase anxiety-related behaviors.

PloS one - 2 Nov 2009

Sarrazin Nadège, Di Blasi Francesco, Roullot-Lacarrière Valérie, Rougé-Pont Françoise, Le Roux Anne, Costet Pierre, Revest Jean-Michel, Piazza Pier Vincenzo

Abstract excerpt

The Glucocorticoid Receptor (GR) is a transcription factor ubiquitously expressed in the brain. Activation of brain GRs by high levels of glucocorticoid (GC) hormones modifies a large variety of physiological and pathological-related behaviors. Unfortunately the specific cellular targets of GR-mediated behavioral effects of GC are still largely unknown. To address this issue, we generated a mutated form of the GR...

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Identifiers

PMID: 19888328
DOI: 10.1371/journal.pone.0007704
PMCID: PMC2765620

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Source receipt: pubmed, retrieved 7 Sept 2026.

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