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Article

Neurochemical and behavioral alterations in glucocorticoid receptor-impaired transgenic mice after chronic mild stress.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Mar 2004

Froger Nicolas, Palazzo Enza, Boni Claudette, Hanoun Naïma, Saurini Françoise, Joubert Chantal, Dutriez-Casteloot Isabelle, Enache Michaela, Maccari Stefania, Barden Nicholas, Cohen-Salmon Charles, Hamon Michel, Lanfumey Laurence

Abstract excerpt

Mice (GR-i) bearing a transgene encoding a glucocorticoid receptor (GR) antisense RNA under the control of a neuron-specific neurofilament promoter were used to investigate the effects of a 4 week chronic mild stress (CMS) on the hypothalamo-pituitary-adrenocortical (HPA) axis and the serotoninergic system in a transgenic model of vulnerability to affective disorders. GR-i mice showed a decrease in both...

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Identifiers

PMID: 15028772
DOI: 10.1523/JNEUROSCI.4132-03.2004
PMCID: PMC6729531

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Source receipt: pubmed, retrieved 7 Sept 2026.

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