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Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells

12 Apr 2017

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) is involved in many functions such as neuronal growth, survival, synaptic plasticity and memorization. Altered expression levels are associated with many pathological situations such as depression, epilepsy, Alzheimer's, Huntington's and Parkinson's diseases. Glucocorticoid receptor (GR) is also crucial for neuron functions, via binding of glucocorticoid hormones (GCs). GR...

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PMID: 28403881
DOI: 10.1186/s13041-017-0295-x

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