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Article

A chain initiation factor common to both modular and aromatic polyketide synthases.

Nature - 30 Sept 1999

Bisang C, Long P F, Cortés J, Westcott J, Crosby J, Matharu A L, Cox R J, Simpson T J, Staunton J, Leadlay P F

Abstract excerpt

Antibiotic-producing polyketide synthases (PKSs) are enzymes responsible for the biosynthesis in Streptomyces and related filamentous bacteria of a remarkably broad range of bioactive metabolites, including antitumour aromatic compounds such as mithramycin and macrolide antibiotics such as erythromycin. The molecular basis for the selection of the starter unit on aromatic PKSs is unknown. Here we show that a...

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PMID: 10519556
DOI: 10.1038/46829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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