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Unraveling the iterative type I polyketide synthases hidden in Streptomyces

26 Mar 2020

Abstract excerpt

Type I polyketide synthases (T1PKSs) are one of the most extensively studied PKSs, which can act either iteratively or via an assembly-line mechanism. Domains in the T1PKSs can readily be predicted by computational tools based on their highly conserved sequences. However, to distinguish between iterative and noniterative at the module level remains an overwhelming challenge, which may account for the seemingly...

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PMID: 32217738
DOI: 10.1073/pnas.1917664117

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