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Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases.

ACS chemical biology - 21 Jan 2022

Chisuga Taichi, Nagai Akira, Miyanaga Akimasa, Goto Ena, Kishikawa Kosuke, Kudo Fumitaka, Eguchi Tadashi

Abstract excerpt

Ketosynthase-like decarboxylase (KSQ) domains are widely distributed in the loading modules of modular polyketide synthases (PKSs) and are proposed to catalyze the decarboxylation of a malonyl or methylmalonyl unit for the construction of the PKS starter unit. KSQ domains have high sequence similarity to ketosynthase (KS) domains, which catalyze transacylation and decarboxylative condensation in polyketide and...

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Carboxy-Lyases
Catalytic Domain
Crystallization
Models, Molecular
Polyketide Synthases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Protein Domains

Substrate Specificity

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PMID: 34985877
DOI: 10.1021/acschembio.1c00856

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