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Article

Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase.

Chemistry & biology - 26 Aug 2011

Szu Ping-Hui, Govindarajan Sridhar, Meehan Michael J, Das Abhirup, Nguyen Don D, Dorrestein Pieter C, Minshull Jeremy, Khosla Chaitan

Abstract excerpt

The pentadecaketide fredericamycin has the longest carbon chain backbone among polycyclic aromatic polyketide antibiotics whose biosynthetic genes have been sequenced. This backbone is synthesized by the bimodular fdm polyketide synthase (PKS). Here, we demonstrate that the bimodular fdm PKS as well as its elongation module alone synthesize undecaketides and dodecaketides. Thus, unlike other homologs, the fdm...

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Identifiers

PMID: 21867917
DOI: 10.1016/j.chembiol.2011.07.015
PMCID: PMC3172819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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