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Article

Unprecedented mechanism of chain length determination in fungal aromatic polyketide synthases.

Chemistry & biology - 1 Aug 2004

Watanabe Akira, Ebizuka Yutaka

Abstract excerpt

Fungal aromatic polyketides show remarkable structural diversity fundamentally derived from variations in chain length and cyclization pattern. Their basic skeletons are synthesized by multifunctional iterative type I polyketide synthases (PKSs). Recently, we have found that the C-terminal thioesterase (TE)-like domain of Aspergillus nidulans WA catalyzes Claisen-type cyclization to form the B-ring of...

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Identifiers

PMID: 15324811
DOI: 10.1016/j.chembiol.2004.05.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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