Article
Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes.
Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 1999
Gonzalez E, Bamshad M, Sato N, Mummidi S, Dhanda R, Catano G, Cabrera S, McBride M, Cao X H, Merrill G, O'Connell P, Bowden D W, Freedman B I, Anderson S A, Walter E A, Evans J S, Stephan K T, Clark R A, Tyagi S, Ahuja S S, Dolan M J, Ahuja S K
Abstract excerpt
Genetic variation in CC chemokine receptor 5 (CCR5), the major HIV-1 coreceptor, has been shown to influence HIV-1 transmission and disease progression. However, it is generally assumed that the same CCR5 genotype (or haplotype) has similar phenotypic effects in different populations. To test this assumption, we used an evolutionary-based classification of CCR5 haplotypes to determine their associated HIV-1...
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