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Article

Allelic variants of human beta-chemokine receptor 5 (CCR5) promoter: evolutionary relationships and predictable associations with HIV-1 disease progression.

Genes and immunity - 1 Sept 1999

Tang J, Rivers C, Karita E, Costello C, Allen S, Fultz P N, Schoenbaum E E, Kaslow R A

Abstract excerpt

Variability in the natural history of HIV-1 infection has been repeatedly associated with genetic variants in the beta-chemokine receptor 5 (CCR5) locus. While CCR5 coding sequences have demonstrated relatively limited variation, sequences of its promoter appear polymorphic in all major populations. Our studies revealed five major CCR5 promoter alleles with distributions that differed widely among the four...

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PMID: 11197301
DOI: 10.1038/sj.gene.6363640

Genes

CCR5

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