Article
Genetic acceleration of AIDS progression by a promoter variant of CCR5.
Science (New York, N.Y.) - 4 Dec 1998
Martin M P, Dean M, Smith M W, Winkler C, Gerrard B, Michael N L, Lee B, Doms R W, Margolick J, Buchbinder S, Goedert J J, O'Brien T R, Hilgartner M W, Vlahov D, O'Brien S J, Carrington M
Abstract excerpt
The CCR5 gene encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for macrophage-tropic (R5) strains of human immunodeficiency virus-type 1 (HIV-1). Genetic association analysis of five cohorts of people with acquired immunodeficiency syndrome (AIDS) revealed that infected individuals homozygous for a multisite haplotype of the CCR5 regulatory region containing...
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