Article
Genetic acceleration of AIDS progression by a promoter variant of CCR5.
Science (New York, N.Y.) - 4 Dec 1998
Martin M P, Dean M, Smith M W, Winkler C, Gerrard B, Michael N L, Lee B, Doms R W, Margolick J, Buchbinder S, Goedert J J, O'Brien T R, Hilgartner M W, Vlahov D, O'Brien S J, Carrington M
Abstract excerpt
The CCR5 gene encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for macrophage-tropic (R5) strains of human immunodeficiency virus-type 1 (HIV-1). Genetic association analysis of five cohorts of people with acquired immunodeficiency syndrome (AI...
Topics
- Acquired Immunodeficiency Syndrome
- Alleles
- Chemokine CXCL12
- Chemokines, CXC
- Cohort Studies
- Disease Progression
- Genes, Dominant
- Genes, Recessive
- Genetic Predisposition to Disease
- Genotype
- HIV Infections
- HIV-1
- Haplotypes
- Heterozygote