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Article

A strong signature of balancing selection in the 5' cis-regulatory region of CCR5.

Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2002

Bamshad Michael J, Mummidi Srinivas, Gonzalez Enrique, Ahuja Seema S, Dunn Diane M, Watkins W Scott, Wooding Stephen, Stone Anne C, Jorde Lynn B, Weiss Robert B, Ahuja Sunil K

Abstract excerpt

CCR5 encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for HIV-type 1 (HIV-1). Varied HIV-1 susceptibility and time to progression to AIDS have been associated with polymorphisms in CCR5. Many of these polymorphisms are located in the 5' cis-regulatory region of CCR5, suggesting that it may have been a target of natural selection. We characterized CCR5 sequence...

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Identifiers

PMID: 12149450
DOI: 10.1073/pnas.162046399
PMCID: PMC124967

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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