Article
Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002
Takashima Seiji, Kitakaze Masafumi, Asakura Masanori, Asanuma Hiroshi, Sanada Shoji, Tashiro Fumi, Niwa Hitoshi, Miyazaki Ji Jun-ichi, Hirota Seiichi, Kitamura Yukihiko, Kitsukawa Takashi, Fujisawa Hajime, Klagsbrun Michael, Hori Masatsugu
Abstract excerpt
Neuropilins (NP1 and NP2) are vascular endothelial growth factor (VEGF) receptors that mediate developmental and tumor angiogenesis. Transgenic mice, in which both NP1 and NP2 were targeted (NP1(-/-)NP2(-/-)) died in utero at E8.5. Their yolk sacs were totally avascular. Mice deficient for NP2 but heterozygous for NP1 (NP1(+/-)NP2(-/-)) or deficient for NP1 but heterozygous for NP2 (NP1(-/-)NP2(+/-)) were also...
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