Article
Neuropilin-1 on hematopoietic cells as a source of vascular development.
Blood - 1 Mar 2003
Yamada Yoshihiro, Oike Yuichi, Ogawa Hisao, Ito Yasuhiro, Fujisawa Hajime, Suda Toshio, Takakura Nobuyuki
Abstract excerpt
Neuropilin-1 (NP-1) is a receptor for vascular endothelial growth factor-165 (VEGF165) and acts as a coreceptor that enhances the function of VEGF165 through VEGF receptor-2 (VEGFR-2). Studies using transgenic and knock-out mice of NP-1 indicated that this molecule is important for vascular development as well as neuronal development. We recently reported that clustered soluble NP-1 phosphorylates VEGFR-2 on...
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