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Article

Abnormal lymphatic vessel development in neuropilin 2 mutant mice

15 Oct 2002

Abstract excerpt

Neuropilin 2 is a receptor for class III semaphorins and for certain members of the vascular endothelial growth factor family. Targeted inactivation of the neuropilin 2 gene (Nrp2) has previously shown its role in neural development. We report that neuropilin 2 expression in the vascular system is restricted to veins and lymphatic vessels. Homozygous Nrp2 mutants show absence or severe reduction of small...

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PMID: 12361971
DOI: 10.1242/dev.129.20.4797

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