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Article

Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study.

Neurobiology of disease - 1 Dec 2011

Chong Seon-Ah, Benilova Iryna, Shaban Hamdy, De Strooper Bart, Devijver Herman, Moechars Dieder, Eberle Wolfgang, Bartic Carmen, Van Leuven Fred, Callewaert Geert

Abstract excerpt

APP.V717I and Tau.P301L transgenic mice develop Alzheimer's disease pathology comprising important aspects of human disease including increased levels of amyloid peptides, cognitive and motor impairment, amyloid plaques and neurofibrillary tangles. The combined model, APP.V717I×Tau.P301L bigenic mice (biAT mice) exhibit aggravated amyloid and tau pathology with severe cognitive and behavioral defects. In the...

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PMID: 21807097
DOI: 10.1016/j.nbd.2011.07.006

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APP

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