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Article

In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice.

Brain research - 8 Sept 2000

Giacchino J, Criado J R, Games D, Henriksen S

Abstract excerpt

Alzheimer's disease (AD) is characterized by progressive neurodegeneration and cognitive impairment. We examined in vivo alterations in hippocampal neurotransmission in both young and aged PDAPP transgenic mice and nontransgenic littermates. We now report that in vivo abnormal neurotransmission in hippocampal circuits of PDAPP mice precedes beta deposition and neurodegeneration. These in vivo data provide the...

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Identifiers

PMID: 10973607
DOI: 10.1016/s0006-8993(00)02615-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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