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Article

Long-term potentiation is increased in the CA1 area of the hippocampus of APP(swe/ind) CRND8 mice.

Neurobiology of disease - 1 Dec 2002

Jolas Thierry, Zhang Xue-Song, Zhang Qi, Wong Gwendolyn, Del Vecchio Robert, Gold Lisa, Priestley Tony

Abstract excerpt

The present study reports changes in synaptic function and plasticity [long-term potentiation (LTP)] in a recently developed mouse model of Alzheimer's disease (CRND8 line) harboring a double amyloid precursor protein mutation (APP(swe/ind)). In 9-week-old preplaque transgenic (Tg) mice brain slices, basal synaptic function in the hippocampal CA1 area was unchanged. Only one of three different LTP induction...

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Source

Identifiers

PMID: 12586549
DOI: 10.1006/nbdi.2002.0557

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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