Article
Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice.
PloS one - 22 Mar 2010
Gengler Simon, Hamilton Alison, Hölscher Christian
Abstract excerpt
BACKGROUND: Alzheimer disease (AD) is a neurodegenerative disorder for which there is no cure. We have investigated synaptic plasticity in area CA1 in a novel AD mouse model (APPPS1-21) which expresses the Swedish mutation of APP and the L166P mutation of human PS-1. This model shows initial plaq...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Disease Models, Animal
- Female
- Genotype
- Heterozygote
- Hippocampus
- Long-Term Potentiation
- Male
- Mice
- Mice, Inbred C57BL
- Neuronal Plasticity
- Synapses
- Synaptic Transmission