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Distinct In Vivo Roles of Caspase-8 in β-Cells in Physiological and Diabetes Models

28 Aug 2007

Abstract excerpt

Inadequate pancreatic beta-cell mass resulting from excessive beta-cell apoptosis is a key defect in type 1 and type 2 diabetes. Caspases are the major molecules involved in apoptosis; however, in vivo roles of specific caspases in diabetes are unclear. The purpose of this study is to examine the role of Caspase (Casp)8 in beta-cells in vivo. Using the Cre-loxP system, mice lacking Casp8 in beta-cells...

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PMID: 17563067
DOI: 10.2337/db06-1771

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