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Article

Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose.

The Journal of biological chemistry - 4 Oct 2002

Shiota Chiyo, Larsson Olof, Shelton Kathy D, Shiota Masakazu, Efanov Alexander M, Hoy Marianne, Lindner Jill, Kooptiwut Suwattanee, Juntti-Berggren Lisa, Gromada Jesper, Berggren Per-Olof, Magnuson Mark A

Abstract excerpt

The ATP-sensitive potassium channel is a key molecular complex for glucose-stimulated insulin secretion in pancreatic beta cells. In humans, mutations in either of the two subunits for this channel, the sulfonylurea type 1 receptor (Sur1) or Kir6.2, cause persistent hyperinsulinemic hypoglycemia...

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PMID: 12149271
DOI: 10.1074/jbc.M206757200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12149271-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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