Article
Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose.
The Journal of biological chemistry - 4 Oct 2002
Shiota Chiyo, Larsson Olof, Shelton Kathy D, Shiota Masakazu, Efanov Alexander M, Hoy Marianne, Lindner Jill, Kooptiwut Suwattanee, Juntti-Berggren Lisa, Gromada Jesper, Berggren Per-Olof, Magnuson Mark A
Abstract excerpt
The ATP-sensitive potassium channel is a key molecular complex for glucose-stimulated insulin secretion in pancreatic beta cells. In humans, mutations in either of the two subunits for this channel, the sulfonylurea type 1 receptor (Sur1) or Kir6.2, cause persistent hyperinsulinemic hypoglycemia of infancy. We have generated and characterized Sur1 null mice. Interestingly, these animals remain euglycemic for a...
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