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Article

Methylation sequencing analysis refines the region of H19 epimutation in Wilms tumor.

The Journal of biological chemistry - 8 Oct 1999

Frevel M A, Sowerby S J, Petersen G B, Reeve A E

Abstract excerpt

Differential DNA methylation of the parental alleles has been implicated in the establishment and maintenance of the monoallelic expression of imprinted genes. H19 and IGF2 are oppositely imprinted with only the maternal and the paternal alleles expressed, respectively. In Wilms tumor, a childhood renal neoplasm, loss of the H19/IGF2 imprinted expression pattern results in silencing of H19 and biallelic...

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Source

Identifiers

PMID: 10506193
DOI: 10.1074/jbc.274.41.29331

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylation sequencing analysis refines the region of H19 epimutation in Wilms tumor.PMID 10506193Read ↗

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