Article
H19 gene polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study.
Molecular genetics & genomic medicine - 1 Feb 2021
Li Wenya, Hua Rui-Xi, Wang Mi, Zhang Da, Zhu Jinhong, Zhang Songyang, Yang Yang, Cheng Jiwen, Zhou Haixia, Zhang Jiao, He Jing
Abstract excerpt
BACKGROUND: Wilms tumor is the most common pediatric renal cancer. However, genetic bases behind Wilms tumor remain largely unknown. H19 is a critical maternally imprinted gene. Previous studies indicated that single nucleotide polymorphisms (SNPs) in the H19 can modify the risk of several human malignancies. Epigenetic errors at the H19 locus lead to biallelic silencing in Wilms tumors. Genetic variations in the...
Topics
- Child, Preschool
- China
- Female
- Genes, Modifier
- Humans
- Infant
- Male
- Polymorphism, Single Nucleotide
- RNA, Long Noncoding
- Wilms Tumor