Epigenetic lesions at the H19 locus in Wilms' tumour patients.

doi:10.1038/ng0794-440

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Article

Epigenetic lesions at the H19 locus in Wilms' tumour patients.

Nature genetics - 1 Jul 1994

Moulton T, Crenshaw T, Hao Y, Moosikasuwan J, Lin N, Dembitzer F, Hensle T, Weiss L, McMorrow L, Loew T, Kraus W, Gerald W, Tycko B

Abstract excerpt

To test the potential role of H19 as a tumour suppressor gene we have examined its expression and DNA methylation in Wilms' tumours (WTs). In most WTs (18/25), H19 RNA was reduced at least 20-fold from fetal kidney levels. Of the expression-negative tumours ten retained 11p15.5 heterozygosity: in...

Topics

Alleles
DNA, Neoplasm
Enhancer Elements, Genetic
Female
Gene Expression Regulation, Neoplastic
Genes
Genes, Tumor Suppressor
Genes, ras
Genomic Imprinting
Genotype
Humans
Insulin-Like Growth Factor II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kidney

Kidney Neoplasms

Male

Methylation

Oncogenes

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 7920666
DOI: 10.1038/ng0794-440

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7920666-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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