Article

Novel epigenetic signature, molecular subtypes and insights into IGF2/H19 dysregulation in Wilms tumour revealed by methylomic and transcriptomic profiling

2025-11-11

Abstract excerpt

<title>Abstract</title> <p> Wilms tumour (WT), the most common kidney cancer in children, results from disrupted kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting <italic>IGF2</italic> and <italic>H19</italic> genes. The epigenetic landscape beyond 11p15.5 suggests diagnostic and prognostic potential, but its link to transcriptomic changes is largely u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e89d9cfa-0201-5d10-9917-91c69455d703
DOI: 10.21203/rs.3.rs-8030860/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel epigenetic signature, molecular subtypes and insights into IGF2/H19 dysregulation in Wilms tumour revealed by methylomic and transcriptomic profilingDOI 10.21203/rs.3.rs-8030860/v1Read

Methylome analysis identifies a Wilms tumor epigenetic biomarker detectable in bloodSemantic proximity Read

Comparative methylome analysis identifies new tumour subtypes and biomarkers for transformation of nephrogenic rests into Wilms tumourSemantic proximity Read

Clinically and biologically relevant subgroups of Wilms tumour defined by genomic and epigenomic analyses.Semantic proximity Read

Clinically relevant subsets identified by gene expression patterns support a revised ontogenic model of Wilms tumor: a Children's Oncology Group Study.Semantic proximity Read

Cancer predisposition signaling in Beckwith-Wiedemann Syndrome drives Wilms tumor development.Semantic proximity Read

Novel deletion in 11p15.5 imprinting center region 1 in a patient with Beckwith-Wiedemann syndrome provides insight into distal enhancer regulation and tumorigenesis.Semantic proximity Read

The genetic factors contributing to the development of Wilm's tumor and their clinical utility in its diagnosis and prognosis.Semantic proximity Read

Distinct Methylation Changes at the IGF2-H19 Locus in Congenital Growth Disorders and CancerSemantic proximity Read

Distinct pathways for genetic and epigenetic predisposition in familial and bilateral Wilms tumor.Semantic proximity Read

Pathway-centric multi-omics and functional precision medicine reveal shared drug vulnerabilities in heterogeneous adult Wilms tumorSemantic proximity Read

Recent advances in Wilms' tumor predisposition.Semantic proximity Read

Integrative Transcriptomic Profiling Reveals Novel Biomarkers in Wilms TumorSemantic proximity Read