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Article

Generation of soluble P- and E-selectins in vivo is dependent on expression of P-selectin glycoprotein ligand-1.

Journal of thrombosis and haemostasis : JTH - 1 Mar 2007

Bodary P F, Homeister J W, Vargas F B, Wickenheiser K J, Cudney S S, Bahrou K L, Ohman M, Rabbani A B, Eitzman D T

Abstract excerpt

BACKGROUND: Factors contributing to the generation of soluble P- and E-selectins remain unclear. RESULTS: This work demonstrates that mice lacking P-selectin glycoprotein ligand-1 (Psgl-1(-/-)) are deficient in soluble P-selectin (sP-sel), which is due to a defective binding interaction between PSGL-1 and P-sel, because mice lacking alpha(1,3)-fucosyltransferase-VII are also deficient in sP-sel. Psgl-1(-/-) mice...

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Identifiers

PMID: 17229053
DOI: 10.1111/j.1538-7836.2007.02388.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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