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Article

Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene.

Cancer research - 15 Jan 2010

Schaaf Gerben, Hamdi Mohamed, Zwijnenburg Danny, Lakeman Arjan, Geerts Dirk, Versteeg Rogier, Kool Marcel

Abstract excerpt

RAS oncogenes are among the most frequently mutated genes in human cancer, but effective strategies for therapeutic inhibition of the RAS pathway have been elusive. Sprouty1 (SPRY1) is an upstream antagonist of RAS that is activated by extracellular signal-related kinase (ERK), providing a negative feedback loop for RAS signaling, and other evidence suggests that SPRY1 may have a tumor suppressor function....

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Source

Identifiers

PMID: 20068162
DOI: 10.1158/0008-5472.CAN-09-2532

Genes

SPRY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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