Article
Mitochondria harbouring mutant mtDNA--a cuckoo in the nest?
Biological chemistry - 1 Jan 2000
Hofhaus G, Gattermann N
Abstract excerpt
Mutations of the mitochondrial DNA (mtDNA) are associated with a number of human diseases. To become relevant in terms of pathology, a mutation must generally affect at least 50-70% of mtDNA molecules in a tissue. One way to reach this level is by inheritance. Mitotic segregation of mtDNA in the female germline can result in large increases in the percentage of mutant mtDNA between generations. A different...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.