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Article

Recruitment of healthy mitochondria fuels transmissible cancers.

Trends in genetics : TIG - 1 Jan 2012

Aanen Duur K, Maas Marc F P M

Abstract excerpt

The replication of mitochondrial DNA (mtDNA) is not under strict control of the nucleus. Therefore, within-cell selection can favour mtDNA variants with a replication or survival advantage even if deleterious for the cell. Here, we consider how the balance between selection within and among cells is shifted in cancer cell lineages, and how this affects the somatic evolution of mitochondria. Cancer cell lineages...

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PMID: 22030339
DOI: 10.1016/j.tig.2011.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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