Article
Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism?
Lancet (London, England) - 26 Oct 2002
Chinnery Patrick F, Samuels David C, Elson Joanna, Turnbull Douglass M
Abstract excerpt
In man, cells accumulate somatic mutations of mitochondrial DNA (mtDNA) as part of normal ageing. Although the overall concentration of mutant mtDNA is low in tissue as a whole, very high numbers of various mtDNA mutations develop in individual cells within the same person, which causes age-associated mitochondrial dysfunction. Some tumours contain high numbers of mtDNA mutations that are not present in healthy...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.