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Article

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection.

Nature genetics - 1 Jun 2001

Coller H A, Khrapko K, Bodyak N D, Nekhaeva E, Herrero-Jimenez P, Thilly W G

Abstract excerpt

Researchers in several laboratories have reported a high frequency of homoplasmic mitochondrial DNA (mtDNA) mutations in human tumors. This observation has been interpreted to reflect a replicative advantage for mutated mtDNA copies, a growth advantage for a cell containing certain mtDNA mutations, and/or tumorigenic properties of mtDNA mutations. We consider another possibility-that the observed homoplasmy arose...

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PMID: 11381261
DOI: 10.1038/88859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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