Article
Where and when do somatic mtDNA mutations occur?
Annals of the New York Academy of Sciences - 1 Jun 2004
Khrapko Konstantin, Ebralidse Konstantin, Kraytsberg Yevgenya
Abstract excerpt
It is generally assumed that somatic mtDNA mutations are originally created in the cells where these mutations are currently found. Accumulating data indicate, however, that cells with a particular mtDNA mutation tend to "cluster," that is, occur repeatedly within a given sample, but not in the others. Clusters likely are clonal, which implies that mtDNA mutations do not originate in the cells that currently...
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