Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer.

Cancer research - 1 Mar 2005

Pan Hongjie, Califano Joseph, Ponte Jose F, Russo Andrea L, Cheng Kuang-hung, Thiagalingam Arunthathi, Nemani Pratima, Sidransky David, Thiagalingam Sam

Abstract excerpt

Dilution end point loss of heterozygosity (LOH) analysis, a novel approach for the analysis of LOH, was used to evaluate allelic losses with the use of 21 highly polymorphic microsatellite markers at nine chromosomal sites most frequently affected in smoking-related non-small cell lung cancers. Allelotyping was done for bronchial epithelial cells and matching blood samples from 23 former and current smokers and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bronchi
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human

Share to Dermatoglyphics

Share to DNA, Neoplasm

Share to Epithelial Cells

Share to Genetic Heterogeneity

Share to Loss of Heterozygosity

Source

Identifiers

PMID: 15753360
DOI: 10.1158/0008-5472.CAN-04-3297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer.PMID 15753360Read ↗

Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma.Semantic proximity Read ↗

Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.Semantic proximity Read ↗

High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.Semantic proximity Read ↗

Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancerSemantic proximity Read ↗

Allelotype of non-small cell lung carcinoma--comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma.Semantic proximity Read ↗

Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types.Semantic proximity Read ↗

Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma.Semantic proximity Read ↗

Deletions at chromosome 2q and 12p are early and frequent molecular alterations in bronchial epithelium and NSCLC of long-term smokersSemantic proximity Read ↗

Molecular mechanisms underlying the regulation of tumour suppressor genes in lung cancer.Semantic proximity Read ↗

Fractional allele loss data indicate distinct genetic populations in the development of non-small-cell lung cancer.Semantic proximity Read ↗

Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung.Semantic proximity Read ↗

Somatic genetic changes accompanying lung tumor development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.