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Article

Loss of heterozygosity and the smoking index increase with decrease in differentiation of lung adenocarcinomas: etiologic implications.

Cancer letters - 10 Dec 2002

Ishikawa Yuichi, Furuta Reiko, Miyoshi Tatsu, Satoh Yukitoshi, Okumura Sakae, Nakagawa Ken, Tsuchiya Eiju

Abstract excerpt

To better understand causative relations of smoking to lung adenocarcinomas, the frequency of loss of heterozygosity (LOH) of all autosomal chromosomes was compared among the three grades of histological differentiation with 119 pulmonary adenocarcinomas (AC) and 41 squamous cell carcinomas (SCC), using Southern blotting. The fractional allelic loss (FAL) values, defined as (number of chromosome arms with...

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Identifiers

PMID: 12359350
DOI: 10.1016/s0304-3835(02)00383-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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