Article
Multiple high-grade bronchial dysplasia and squamous cell carcinoma: concordant and discordant mutations.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2001
Boyle J O, Lonardo F, Chang J H, Klimstra D, Rusch V, Dmitrovsky E
Abstract excerpt
Loss of heterozygosity (LOH) involving chromosomes 3p, 5q, 9p, or 17p and aberrant expression or mutation of p53 are reported previously in selected bronchial dysplasias and squamous cell cancers (SCCs). Yet, comprehensive analyses of LOH patterns at these chromosomal sites and of p53 alterations...
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