Article
Molecular changes in the bronchial epithelium of patients with small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2000
Wistuba I I, Berry J, Behrens C, Maitra A, Shivapurkar N, Milchgrub S, Mackay B, Minna J D, Gazdar A F
Abstract excerpt
To better understand the pathways involved in the pathogenesis of small cell lung carcinoma (SCLC), we compared the patterns of molecular changes present in these tumors and their accompanying bronchial epithelium with those present in the other two major types of lung cancer [squamous cell carcinoma (SQC) and adenocarcinoma (ADC)]. We obtained DNA from 68 microdissected invasive lung tumors (22 SCLCs, 21 ADCs,...
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