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Article

A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1.

Nucleic acids research - 15 Sept 1999

Knoepfler P S, Bergstrom D A, Uetsuki T, Dac-Korytko I, Sun Y H, Wright W E, Tapscott S J, Kamps M P

Abstract excerpt

The t(1;19) chromosomal translocation of pediatric pre-B cell leukemia produces chimeric oncoprotein E2a-Pbx1, which contains the N-terminal transactivation domain of the basic helix-loop-helix (bHLH) transcription factor, E2a, joined to the majority of the homeodomain protein, Pbx1. There are three Pbx family members, which bind DNA as heterodimers with both broadly expressed Meis/Prep1 homeo-domain proteins and...

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Identifiers

PMID: 10471746
DOI: 10.1093/nar/27.18.3752
PMCID: PMC148632

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