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Article

Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia.

Molecular and cellular biology - 1 Jan 2001

Thorsteinsdottir U, Kroon E, Jerome L, Blasi F, Sauvageau G

Abstract excerpt

Complex genetic and biochemical interactions between HOX proteins and members of the TALE (i.e., PBX and MEIS) family have been identified in embryonic development, and some of these interactions also appear to be important for leukemic transformation. We have previously shown that HOXA9 collaborates with MEIS1 in the induction of acute myeloid leukemia (AML). In this report, we demonstrate that HOXB3, which is...

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Source

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Identifiers

PMID: 11113197
DOI: 10.1128/MCB.21.1.224-234.2001
PMCID: PMC88796

Genes

MEIS1
HOXA9
HOXB3
PBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia.PMID 11113197Read ↗

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The Role of Hox Proteins in Leukemogenesis: Insights Into Key Regulatory Events in HematopoiesisSemantic proximity Read ↗

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PBX3 is an important cofactor of HOXA9 in leukemogenesisSemantic proximity Read ↗

Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus.Semantic proximity Read ↗

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